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CRC1366

Vascular Control of Organ Function

Prof. Dr. Ralf Adams

Director, Max Planck Institute for Molecular Biomedicine, Münster

Department Tissue Morphogenesis

ralf.adams(at)mpi-muenster.mpg.de

Professional Career

Since 2019

Adjunct Professor

University of Münster, Germany

Since 2007

Director

Max Planck Institute for Molecular Biomedicine, Münster, Germany

2007 - 2018

Full Professor

University of Münster, Germany

2000 - 2008

Head of the Vascular Development Laboratory

and tenured Senior Group Leader

Cancer UK London Research Institute, UK

1996

Ph.D.

in Biochemistry, Johann Wolfgang Goethe University, Frankfurt

1996 - 2000

Postdoctoral Research Fellow

EMBL Heidelberg, Germany

Selected Publications

Pitulescu ME, Schmidt I, Giaimo BD, Antoine T, Berkenfeld F, Ferrante F, Park H, Ehling M, Biljes D, Rocha SF, Langen UH, Stehling M, Nagasawa T, Ferrara N, Borggrefe T, Adams RH: Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nat Cell Biol. 19:915-927, 2017.

Langen UH, Pitulescu ME, Kim JM, Enriquez-Gasca R, Sivaraj KK, Kusumbe AP, Singh A, Di Russo J, Bixel MG, Zhou B, Sorokin L, Vaquerizas JM, Adams RH: Cell-matrix signals specify bone endothelial cells during developmental osteogenesis. Nat Cell Biol. 19:189-201, 2017.

Kusumbe AP, Ramasamy SK, Itkin T, Mäe MA, Langen UH, Betsholtz C, Lapidot T, Adams RH: Age-dependent modulation of vascular niches for haematopoietic stem cells. Nature. 532:380-4, 2016.

Ramasamy SK, Kusumbe AP, Schiller M, Zeuschner D, Bixel MG, Milia C, Gamrekelashvili J, Limbourg A, Medvinsky A, Santoro MM, Limbourg FP, Adams RH: Blood flow controls bone vascular function and osteogenesis. Nat Comm. 7:13601, 2016.

Ramasamy SK, Kusumbe AP, Wang L, Adams RH: Endothelial Notch activity promotes angiogenesis and osteogenesis in bone. Nature. 507:376-80, 2014.

Kusumbe AP, Ramasamy SK, Adams RH: Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone. Nature. 507:323-8, 2014.

Nakayama M, Nakayama A, van Lessen M, Yamamoto H, Hoffmann S, Drexler HC, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH: Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat Cell Biol. 15:249-260, 2013.

Wang Y, Nakayama M, Pitulescu ME, Schmidt TS, Bochenek ML, Sakakibara A, Adams S, Davy A, Deutsch U, Lüthi, U, Barberis A, Benjamin LE, Mäkinen T, Nobes CD, Adams RH: Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature. 465:483-486, 2010.

Benedito R, Roca C, Sörensen I, Adams S, Gossler A, Fruttiger M, Adams RH: The Notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell. 137:1124-1135, 2009.

Foo SS, Turner CJ, Adams S, Compagni A, Aubyn D, Kogata N, Lindblom P, Shani M, Zicha D, Adams RH: Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell. 124:161-173, 2006.

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