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Prof. Dr. Andreas Fischer

Project C04

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Institute for Clinical Chemistry

University Medical Center Göttingen (UMG)

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andreas.fischer(at)med.uni-goettingen.de

Professional Career

Since 2021

Professor and Chair

Clinical Chemistry and Medical Director of Interdisciplinary
UMG Laboratories, University of Göttingen, Germany

2017 - 2022

Head of Division

Vascular Signalling and Cancer

German Cancer Research Center (DKFZ), Heidelberg, Germany

2012 - 2017

Head

Helmholtz Young Investigators Group

German Cancer Research Center (DKFZ), Heidelberg, Germany

2007 - 2012

Resident and Lecturer

Research Division Vascular Biology

Medical Faculty Mannheim, University of Heidelberg, Germany

2004 - 2007

Resident and Lecturer

Institute of Physiological Chemistry

Biocenter, University of Würzburg, Germany

2002 - 2004

Arzt im Praktikum

Institute of Human Genetics

University Hospital Würzburg, Germany

2003

MD

University of Würzburg, Germany

Selected Publications

Weis EM, Puchalska P, Nelson A, Taylor J, Moll I, Hasan SS, Dewenter M, Hagenmueller M, Fleming T, Poschet G, Hotz-Wagenblatt A, Backs J, Crawford P, Fischer A: Ketone body oxidation increases cardiac endothelial cell proliferation. EMBO Mol Med, e14753. 2022.


Alsina-Sanchis E, Mülfarth R, Moll I, Mogler C, Rodriguez-Vita J, Fischer A: Intraperitoneal oil application causes local inflam-mation with depletion of resident peritoneal macrophages. Mol Cancer Res, 19:288-300, 2021.


Hasan SS, Jabs M, Taylor J, Wiedmann L, Leibing T, Nordström V, Federico G, Roma LP, Carlein C, Wolff G, Ekim-Üstünel B, Brune M, Moll I, Tetzlaff F, Gröne HJ, Fleming T, Géraud C, Herzig S, Nawroth PP, Fischer A: Endothelial Notch signaling controls insulin transport in muscle. EMBO Mol Med, 12:e09271, 2020.


Tetzlaff F, Adam MG, Feldner A, Moll I, Menuchin A, Rodriguez-Vita J, Sprinzak D, Fischer A: MPDZ promotes DLL4-induced Notch signaling during angiogenesis. elife, 7:e32860, 2018.


Jabs M, Rose AJ, Lehmann LH, Taylor J, Moll I, Sijmonsma TP, Herberich SE, Sauer SW, Poschet G, Federico G, Mogler C, Weis EM, Augustin HG, Yan M, Gretz N, Schmid RM, Adams RH, Gröne HJ, Hell R, Okun JG, Backs J, Nawroth PP, Herzig S, Fischer A: Inhibition of endothelial notch signaling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart. Circulation, 137:2592-2608, 2018.


Wieland E, Rodriguez-Vita J, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A: Endothelial Notch1 activity facilitates metastasis. Cancer Cell, 31:355-67, 2017.


Yang WJ, Hu J, Uemura A, Tetzlaff F, Augustin HG, Fischer A: Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis. EMBO Mol Med, 7:1267-84, 2015.


Adam MG, Berger C, Feldner A, Yang WJ, Wüstehube-Lausch J, Herberich SE, Pinder M, Gesierich S, Hammes HP, Augustin HG, Fischer A: Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. Circ Res, 113:1206-18, 2013.


Brütsch R, Liebler SS, Wüstehube J, Bartol A, Herberich SE, Adam MG, Telzerow A, Augustin HG, Fischer A: Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis. Circ Res, 107:592-601, 2010.


Wüstehube J, Bartol A, Liebler SS, Brütsch R, Zhu Y, Felbor U, Sure U, Augustin HG, Fischer A: Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling. Proc Natl Acad Sci U S A, 107:12640-5, 2010.

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