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CRC1366

Vascular Control of Organ Function

Prof. Dr. Hellmut Augustin

Project C05 | Project Z01

European Center for Angioscience (ECAS)
Medical Faculty Mannheim, Heidelberg University
German Cancer Research Center Heidelberg

augustin(at)angiogenese.de

Professional Career

Since 2017

Founding Director

European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University

Since 2016

Full Professor

Department of Vascular Biology and Tumor Angiogenesis, Medical Faculty Mannheim, Heidelberg University, and German Cancer Research Center (DKFZ), Heidelberg, Germany

2006 - 2016

Aventis Foundation-endowed Chair

Vascular Biology and Angiogenesis Research, Medical Faculty Mannheim (CBTM), Heidelberg University, and German Cancer Research Center, Heidelberg, Germany

2001 - 2006

Head

Department of Vascular Biology & Angiogenesis Research, Tumor Biology Center, Freiburg, Germany

1992 - 2001

Research Assistant Professor

University of Göttingen, Germany

1988 - 1992

Ph.D.

in Experimental Pathology, Cornell University, Ithaca, USA

1984 - 1987

Residency and Graduate Training

in Veterinary Pathology, Hannover, Germany

1978 - 1984

Veterinary Medicine

School of Veterinary Medicine Hannover, Germany

Selected Publications

Singhal M*, Gengenbacher N*, Abdul Pari AA*, Kamiyama M, Hai L, Kuhn BJ, Kallenberg DM, Kulkarni SR, Camilli C, Preuss SF, Leuchs B, Mogler C, Espinet E, Besemfelder E, Heide D, Heikenwalder M, Sprick MR, Trumpp A, Krijgsveld J, Schlesner M, Hu J, Moss SE, Greenwood J, Augustin HG: Temporal multi-omics identifies LRG1 as a vascular niche instructor of metastasis. Science Transl Med. 13:eabe6805, 2021. (*equal contribution)

Gengenbacher N*, Singhal M*, Mogler C, Hai L, Milde L, Abdul Pari AA, Besemfelder E, Fricke C, Baumann D, Gehrs S, Utikal J, Felcht M, Hu J, Schlesner M, Offringa R, Chintharlapalli SR, Augustin HG: Timed Ang2-targeted therapy identifies the Angiopoietin-Tie pathway as key regulator of fatal lymphogenous metastasis. Cancer Discov. 11:424-45, 2021.

Inverso D*, Shi J*, Lee KH, Jakab M, Ben-Moshe S, Kulkarni SR, Schneider M, Wang G, Komeili M, Argos Vélez P, Riedel M, Spegg C, Ruppert T, Schaeffer-Reiss C, Helm D, Singh I, Boutros M, Chintharlapalli S, Heikenwalder M, Itzkovitz S, Augustin HG: A spatial vascular transcriptomic, proteomic and phosphoproteomic atlas unveils an angiocrine Tie Wnt signaling axis in the liver. Dev Cell. 56:1677-1693, 2021. (*equal contribution)

Singhal M, Gengenbacher N, La Porta S, Gehrs S, Shi J, Kamiyama M, Bodenmiller DM, Fischl A, Schieb B, Besemfelder E, Chintharlapalli S, Augustin HG: Preclinical validation of a novel metastasis-inhibiting Tie1 function-blocking antibody. EMBO Mol Med. 12:e11163, 2020.

Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C, Augustin HG: The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. eLife. 7:e34423, 2018.

La Porta S, Roth L, Singhal M, Mogler C, Spegg C, Schieb B, Qu X, Adams RH, Baldwin HS, Savant S, Augustin HG: Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis. J Clin Invest. 128:834-845, 2018.

Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K, Augustin HG: Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat Commun. 8:16106, 2017.

Scholz B, Korn C, Wojtarowicz J, Mogler C, Augustin I, Boutros M, Niehrs C, Augustin HG: Endothelial RSPO3 controls vascular stability and pruning through non-canonical WNT/Ca(2+)/NFAT signaling. Dev Cell. 36:79-93, 2016.

Hu J*, Srivastava K*, Wieland M, Runge A, Mogler C, Besemfelder E, Terhardt D, Vogel MJ, Cao L, Korn C, Bartels S, Thomas M, Augustin HG: Endothelial cell-derived Angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat. Science. 343:416-9, 2014. (*equal contribution)

Srivastava K*, Hu J*, Korn C, Savant S, Teichert M, Kapel S, Jugold M, Besemfelder E, Thomas M, Pasparakis M, Augustin HG: Postsurgical adjuvant tumor therapy by combining anti-Angiopoietin-2 and metronomic chemotherapy limits metastatic growth. Cancer Cell. 26:880-95, 2014. (*equal contribution)

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