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CRC1366

Vascular Control of Organ Function

Prof. Dr. Stefanie Dimmeler

European Center for Angioscience (ECAS)
Medical Faculty Mannheim, Heidelberg University
German Cancer Research Center Heidelberg

dimmeler(at)em.uni-frankfurt.de

Professional Career

Since 2008

Full Professor (W3)

Director of the Institute of Cardiovascular Regeneration

Center for Molecular Medicine, University of Frankfurt, Germany

2001 - 2007

Full Professor (C3)

Head of the Department of Molecular Cardiology

University of Frankfurt, Germany

1998 - 2001

Associate Professor (C1)

Head of the Department of Molecular Cardiology

University of Frankfurt, Germany

1995 - 1997

Post-Doctoral Fellow

Department of Molecular Cardiology

University of Frankfurt, Germany

1992 - 1995

Post-Doctoral Fellow

Department of Experimental Surgery

University of Cologne, Germany

1991 - 1993

Ph.D.

Department of Biological Chemistry

University of Konstanz, Germany

Selected Publications

Nicin L, Schroeter SM, Glaser S, Schulze-Brüning R, Pham M-D, Hille SS, Yekelchyk M, Badder K, Abplanalp WT, Tombor L, Müller OJ, Baun T, Meder B, Reich C, Arsalan M, Holubec T, Walther T, Emrich F, Krishnan J, Zeiher AM, John D, Dimmeler S: A human cell atlas of the pressure-induced hypertrophic heart. Nat Cardiovasc Res. 1:174-185, 2022.

Tombor LS, John D, Glaser SF, Luxán G, Forte E, Furtado M, Rosenthal N, Baumgarten N, Schulz MH, Wittig J, Rogg EM, Manavski Y, Fischer A, Muhly-Reinholz M, Klee K, Looso M, Selignow C, Acker T, Bibli SI, Fleming I, Patrick R, Harvey RP, Abplanalp WT, Dimmeler S: Single cell sequencing reveals endothelial plasticity with transient mesenchymal activation after myocardial infarction. Nat Commun. 12:681, 2021.

Hoffmann J, Luxán G, Abplanalp WT, Glaser SF, Rasper T, Fischer A, Muhly-Reinholz M, Potente M, Assmus B, John D, Zeiher AM, Dimmeler S: Post-myocardial infarction heart failure dysregulates the bone vascular niche. Nat Commun. 12:3964, 2021.

Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni N, Martelli F, Pedrazzini T, Dimmeler S, Krishnan J: Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease. Sci Transl Med. 13:eabi7964, 2021.

Glaser SF, Heumüller AW, Tombor L, Hofmann P, Muhly-Reinholz M, Fischer A, Günther S, Kokot KE, Hassel D, Kumar S, Jo H, Boon RA, Abplanalp W, John D, Boeckel JN, Dimmeler S: The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition. Proc Natl Acad Sci U S A. 117: 4180-4187, 2020.

Neumann P, Jaé N, Knau A, Glaser SF, Fouani Y, Rossbach O, Krüger M, John D, Bindereif A, Grote P, Boon RA, Dimmeler S: The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2. Nat Commun. 9:237, 2018.

Manavski Y, Lucas T, Glaser SF, Dorsheimer L, Günther S, Braun T, Rieger MA, Zeiher AM, Boon RA, Dimmeler S: Clonal expansion of endothelial cells contributes to ischemia-induced neovascularization. Circ Res, 122:670-7, 2018.

Stellos K, Gatsiou A, Stamatelopoulos K, Perisic Matic L, John D, Lunella FF, Jaé N, Rossbach O, Amrhein C, Sigala F, Boon RA, Fürtig B, Manavski Y, You X, Uchida S, Keller T, Boeckel JN, Franco-Cereceda A, Maegdefessel L, Chen W, Schwalbe H, Bindereif A, Eriksson P, Hedin U, Zeiher AM, Dimmeler S: Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation. Nat Med, 22:1140-50, 2016.

Boon RA, Iekushi K, Lechner S, Fischer A, Heydt S, Kaluza D, Treguer K, Carmona G, Bonauer A, Horrevoets AJ, Girmatsion Z, Biliczki P, Ehrlich JR, Potente M, Zeiher AM, Hermeking H, Dimmeler S: miRNA-34a regulates cardiac ageing and function. Nature, 495:107-10, 2013.

Hergenreider E, Heydt S, Tréguer K, Boettger T, Horrevoets AJ, Zeiher AM, Scheffer MP, Frangakis AS, Yin X, Mayr M, Braun T, Urbich C, Boon RA, Dimmeler S: Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol, 14:249-56, 2012.

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