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CRC1366

Vascular Control of Organ Function

Prof. Dr. Jörg Heineke

Project A06 | Project Z04

Cardiovascular Physiology, European Center for Angioscience

Medical Faculty Mannheim, Heidelberg University

joerg.heineke(at)medma.uni-heidelberg.de

Professional Career

2017 - 2019

Professor (W3) and Department Head

Cardiovascular Research, Medical Faculty Mannheim,

University of Heidelberg, Germany

2012 - 2017

Heisenberg Professorship (W2)

Experimental Cardiology

Hannover Medical School, Germany

2007 - 2012

Junior Research Group Leader

Klinik für Kardiologie und Angiologie, Cluster of Excellence Rebirth

Med. Hochschule Hanover

2004 - 2007

Postdoctoral Fellow

Cincinnati Children´s Hospital, USA

2000 - 2003

Clinical Fellow

Molecular and translational Cardiology, Departmend of Cardiology
and Angiology, Hannover Medical School, Germany

2001

MD

Departmend of Cardiology and Angiology

Hannover Medical School, Germany,

Selected Publications

Szaroszyk M, Kattih B, Martin-Garrido A, Trogisch FA, Dittrich GM, Grund G, Abouissa A, Derlin K, Meier M, Holler T, Korf-Klingebiel M, Völker K, Macedo TG, Tortola CP, Boschmann M, Huang N, Froese N, Zwadlo C, Malek Mohammadi M, Luo X, Wagner M, Cordero J, Geffers R, Batkai S, Thum T, Bork N, Nikolaev VO, Müller OJ, Katus HA, El-Amouche A, Kraft T, Springer J, Dobreva G, Wollert KC, Fielitz J, von Haehling S, Kuhn M, Bauersachs J, Heineke J: Skeletal muscle derived Musclin protects the heart during pathological overload. Nat Commun, 13:149, 2022.

Dittrich GM, Froese N, Wang X, Kroeger H, Wang H, Szaroszyk M, Malek-Mohammadi M, Cordero J, Keles M, Korf-Klingebiel M, Wollert KC, Geffers R, Mayr M, Conway SJ, Dobreva G, Bauersachs J, Heineke J: Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis. Basic Res Cardiol, 116:26, 2021.

Malek Mohammadi M, Abouissa A, Heineke J: A surgical mouse model of neonatal pressure overload by transverse aortic constriction. Nat Protoc, 16:775-90, 2021.

Grund A, Szaroszyk M, Korf-Klingebiel M, Malek Mohammadi M, Trogisch FA, Schrameck U, Gigina A, Tiedje C, Gaestel M, Kraft T, Hegermann J, Batkai S, Thum T, Perrot A, Remedios CD, Riechert E, Völkers M, Doroudgar S, Jungmann A, Bauer R, Yin X, Mayr M, Wollert KC, Pich A, Xiao H, Katus HA, Bauersachs J, Müller OJ, Heineke J: TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation. EMBO Mol Med, 11:e10018, 2019.

Malek Mohammadi M, Abouissa A, Azizah I, Xie Y, Cordero J, Shirvani A, Gigina A, Engelhardt M, Trogisch FA, Geffers R, Dobreva G, Bauersachs J, Heineke J: Induction of cardiomyocyte proliferation and angiogenesis protects neonatal mice from pressure overload-associated maladaptation. JCI Insight, 5. pii:128336, 2019.

Scharf GM, Kilian K, Cordero J, Wang Y, Grund A, Hofmann M, Froese N, Wang X, Kispert A, Kist R, Conway SJ, Geffers R, Wollert KC, Dobreva G, Bauersachs J, Heineke J: Inactivation of Sox9 in fibroblasts reduces cardiac fibrosis and inflammation. JCI Insight, 5:e128336, 2019.

Appari M*, Breitbart A*, Brandes F, Szaroszyk M, Froese N, Korf-Klingebiel M, Mohammadi MM, Grund A, Scharf GM, Wang H, Zwadlo C, Fraccarollo D, Schrameck U, Nemer M, Wong GW, Katus HA, Wollert KC, Müller OJ, Bauersachs J, Heineke J: C1q-TNF-Related protein-9 promotes cardiac hypertrophy and failure. Circ Res, 120:66-77, 2017.

Malek Mohammadi M, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J: The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO Mol Med, 9:265-79, 2017.

Zwadlo C, Schmidtmann E, Szaroszyk M, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bahre H, Kaever V, Thum T, Bauersachs J, Heineke J: Anti-androgenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction. Circulation, 131:1071-81, 2015.

Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD: CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med, 16:872-9, 2010.

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