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Dr. Katharina Schlereth

Project A05

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European Center for Angioscience (ECAS) 
Medical Faculty Mannheim, Heidelberg University and
German Cancer Research Center Heidelberg (DKFZ)

Professional Career

2019 - 2022

Project Leader

Medical Faculty Mannheim

University of Heidelberg, Germany

2013 - 2018

Postdoctoral Fellow

Deutsches Krebsforschungszentrum (DKFZ)

Heidelberg, Germany

2011 - 2013

Postdoctoral Fellow

Philipps University Marburg, Germany

2007 - 2011

Ph.D.

Philipps University Marburg, Germany

Selected Publications

Schlereth K, Weichenhan D, Bauer T, Heumann T, Giannakouri E, Lipka D, Jaeger S, Schlesner M, Aloy P, Eils R, Plass C, Augustin HG: The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium. eLife, 7:e34423, 2018

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Teichert M, Milde L, Holm A, Stanicek L, Gengenbacher N, Savant S, Ruckdeschel T, Hasanov Z, Srivastava K, Hu J, Hertel S, Bartol A, Schlereth K*, Augustin HG*: Pericyte-expressed Tie2 controls angiogenesis and vessel maturation. Nat Commun, 8:16106, 2017. (*equal contribution)


Schlereth K, Heyl C, Krampitz AM, Mernberger M, Finkernagel F, Scharfe M, Jarek M, Leich E, Rosenwald A, Stiewe T: Characterization of the p53 cistrome-DNA binding cooperativity dissects p53's tumor suppressor functions. PLoS Genet, 9:e1003726, 2013.


Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, Stiewe T, Oren M, Alitalo K, Pikarsky E, Ben-Neriah Y: A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell, 24:242-56, 2013.


Timofeev O, Schlereth K, Wanzel M, Braun A, Nieswandt B, Pagenstecher A, Rosenwald A, Elsässer HP, Stiewe T: p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo. Cell Rep, 3:1512-25, 2013.


Schlereth K*, Beinoraviciute-Kellner R*, Zeitlinger MK, Bretz AC, Sauer M, Charles JP, Vogiatzi F, Leich E, Samans B, Eilers M, Kisker C, Rosenwald A, Stiewe T: DNA binding cooperativity of p53 modulates the decision between cell cycle arrest and apoptosis. Mol Cell, 38:356-68, 2010. (*equal contribution)


Schlereth K, Charles JP, Bretz AC, Stiewe T: Life or death: p53-induced apoptosis requires DNA binding cooperativity. Cell Cycle, 9:4068-76, 2010.


Griesmann H*, Schlereth K*, Krause M, Samans B, Stiewe T: Role of p53 and p73 in suppression of Myc-driven lympho-magenesis. Int J Cancer, 124:502-6, 2009. (*equal contribution)

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