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CRC1366

Vascular Control of Organ Function

Dr. Julian Wagner

Institute of Cardiovascular Regeneration

Goethe University Frankfurt

j.wagner(at)med.uni-frankfurt.de

Professional Career

Since 2021

Elected Speaker

Cardio-Pulmonary Institute (DFG-funded Excellence Cluster)

Since 2020

Post-Doctoral Fellow

Institute of Cardiovascular Regeneration

Goethe University Frankfurt, Germany

2016 - 2020

Ph.D.

Institute of Cardiovascular Regeneration

Goethe University Frankfurt, Germany

Selected Publications

Wagner JUG, Bojkova D, Shumliakivska M, Luxán G, Nicin L, Aslan GS, Milting H, Kandler JD, Dendorfer A, Heumueller AW, Fleming I, Bibli SI, Jakobi T, Dieterich C, Zeiher AM, Ciesek S, Cinatl J, Dimmeler S: Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants. Basic Res Cardiol, 116:42, 2021.

Wenzel J, Lampe J, Müller-Fielitz H, Schuster R, Zille M, Müller K, Krohn M, Körbelin J, Zhang L, Özorhan Ü, Neve V, Wagner JUG, Bojkova D, Shumliakivska M, Jiang Y, Fähnrich A, Ott F, Sencio V, Robil C, Pfefferle S, Sauve F, Coêlho CFF, Franz J, Spiecker F, Lembrich B, Binder S, Feller N, König P, Busch H, Collin L, Villaseñor R, Jöhren O, Altmeppen HC, Pasparakis M, Dimmeler S, Cinatl J, Püschel K, Zelic M, Ofengeim D, Stadelmann C, Trottein F, Nogueiras R, Hilgenfeld R, Glatzel M, Prevot V, Schwaninger M: The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci, 24:1522-33, 2021.

Cremer S, Pilgram L, Berkowitsch A, Stecher M, Rieg S, Shumliakivska M, Bojkova D, Wagner JUG, Aslan GS, Spinner C, Luxán G, Hanses F, Dolff S, Piepel C, Ruppert C, Guenther A, Rüthrich MM, Vehreschild JJ, Wille K, Haselberger M, Heuzeroth H, Hansen A, Eschenhagen T, Cinatl J, Ciesek S, Dimmeler S, Borgmann S, Zeiher A; LEOSS study group: Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease. PLoS One, 16:e0258684, 2021.

McLaughlin KM, Bojkova D, Kandler JD, Bechtel M, Reus P, Le T, Rothweiler F, Wagner JUG, Weigert A, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr: A potential role of the CD47/SIRPalpha Axis in COVID-19 pathogenesis. Curr Issues Mol Biol, 43:1212-25, 2021.

Bojkova D, Wagner JUG, Shumliakivska M, Aslan GS, Saleem U, Hansen A, Luxán G, Günther S, Pham MD, Krishnan J, Harter PN, Ermel UH, Frangakis AS, Milting H, Zeiher AM, Klingel K, Cinatl J, Dendorfer A, Eschenhagen T, Tschöpe C, Ciesek S, Dimmeler S: SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes. Cardiovasc Res, 116:2207-15, 2020.

Wagner JUG, Dimmeler S: Cellular cross-talks in the diseased and aging heart. J Mol Cell Cardiol, 138:136-46, 2020.

Wagner JUG, Pham MD, Nicin L, Hammer M, Bottermann K, Yuan T, Sharma R, John D, Muhly-Reinholz M, Tombor L, Hardt M, Madl J, Dimmeler S, Krishnan J: Dissection of heterocellular cross-talk in vascularized cardiac tissue mimetics. J Mol Cell Cardiol, 138:269-82, 2020.

Cremer S, Kirschbaum K, Berkowitsch A, John D, Kiefer K, Dorsheimer L, Wagner J, Rasper T, Abou-El-Ardat K, Assmus B, Serve H, Rieger M, Dimmeler S, Zeiher AM: Multiple somatic mutations for clonal hematopoiesis are associated with increased mortality in patients with chronic heart failure. Circ Genom Precis Med, 13:e003003, 2020.

Vidal R, Wagner JUG, Braeuning C, Fischer C, Patrick R, Tombor L, Muhly-Reinholz M, John D, Kliem M, Conrad T, Guimarães-Camboa N, Harvey R, Dimmeler S, Sauer S: Transcriptional heterogeneity of fibroblasts is a hallmark of the aging heart. JCI Insight, 4:e131092, 2019.

Wagner JUG, Chavakis E, Rogg EM, Muhly-Reinholz M, Glaser SF, Günther S, John D, Bonini F, Zeiher AM, Schaefer L, Hannocks MJ, Boon RA, Dimmeler S: Switch in Laminin β2 to Laminin β1 Isoforms During Aging Controls Endothelial Cell Functions-Brief Report. Arterioscler Thromb Vasc Biol, 38:1170-7, 2018.

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